Open Access Open Badges Meeting report

Meeting report: Signal transduction meets systems biology

Christine Louis-Dit-Sully1*, Katharina F Kubatzky2*, Jonathan A Lindquist3, Christine Blattner4, Ottmar Janssen5 and Wolfgang W A Schamel16*

Author Affiliations

1 Max Planck Institute of Immunobiology and Epigenetics and Biology III, Faculty of Biology, University of Freiburg, 79108, Freiburg, Germany

2 Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany

3 Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany

4 Karlsruhe Institute of Toxicology and Genetics, PO-Box 3640, 76021, Karlsruhe, Germany

5 Christian-Albrechts-University of Kiel, Institute for Immunology, UKSH Campus Kiel, Arnold-Heller-Str. 3 Bldg 17, 24105, Kiel, Germany

6 Center for Biological Signalling Studies BIOSS, University of Freiburg, 79104 Freiburg and Center for Chronic Immunodeficiency CCI, University Clinics, 79106, Freiburg, Germany

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Cell Communication and Signaling 2012, 10:11  doi:10.1186/1478-811X-10-11

Published: 30 April 2012


In the 21st century, systems-wide analyses of biological processes are getting more and more realistic. Especially for the in depth analysis of signal transduction pathways and networks, various approaches of systems biology are now successfully used. The EU FP7 large integrated project SYBILLA (

ology of T-ce
    ll A
ctivation in Health and Disease) coordinates such an endeavor. By using a combination of experimental data sets and computational modelling, the consortium strives for gaining a detailed and mechanistic understanding of signal transduction processes that govern T-cell activation. In order to foster the interaction between systems biologists and experimentally working groups, SYBILLA co-organized the 15th meeting “Signal Transduction: Receptors, Mediators and Genes” together with the Signal Transduction Society (STS). Thus, the annual STS conference, held from November 7 to 9, 2011 in Weimar, Germany, provided an interdisciplinary forum for research on signal transduction with a major focus on systems biology addressing signalling events in T-cells. Here we report on a selection of ongoing projects of SYBILLA and how they were discussed at this interdisciplinary conference.