|Selected properties of individual murine NFATc proteins expressed in lymphoid cells|
|NFATc1/αA||717||+/+++||(1)||anti-apoptotic, supports proliferation, anti-anergic, oncogenic activity||[24,38,39,90]|
|NFATc1/αC||939||+/+/-||2 (+1)||pro-apoptotic, (inhibits proliferation)||[35,38,39]|
|NFATc2||923-927||(+)/-||2||pro-apoptotic, anti-proliferative, supports anergy induction, tumor suppressor activity||[24,35,56,57,59,90,97,98]|
1) Data from the NCBI database “Gene”. There, two short NFATc2 versions of 452 and 672 aa are also documented. However, their expression and function are unknown. For a comprehensive study about human and murine NFATc RNAs see Ref. .
2) Induction upon immune receptor stimulation in naïve and Th0/Th1 effector T cells and splenic B cells. RNA data were compiled from RNA Seq (E.S. et al., unpubl.) and real time PCR data obtained with splenic T and B cells upon primary stimulation . The protein data reflect the results of Western blot assays . +, 3–5 fold induction; +++, 50 fold induction and more.
3) Existence of SUMO-consensus sites within NFATc proteins. For NFATc1 and c2, their SUMOylation has been demonstrated in vivo[38,97]. (1) for NFATc1 indicates the existence of a “silent” SUMO consensus sites which remains un-used . In NFATc3, two SUMO sites are present but only one corresponds to a “perfect” site.
Serfling et al. Cell Communication and Signaling 2012 10:16 doi:10.1186/1478-811X-10-16