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Correction: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Hui Cai12 and Yan Xu2*

Author Affiliations

1 First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China

2 Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 W. Walnut St. IB355A, Indianapolis, IN 46202, USA

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Cell Communication and Signaling 2013, 11:92  doi:10.1186/1478-811X-11-92

The electronic version of this article is the complete one and can be found online at:

Received:4 December 2013
Accepted:4 December 2013
Published:13 December 2013

© 2013 Cai and Xu; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


In the original paper published [1], there is a mistake in Figure 4. Figure 4D and Figure 4E are the same, but Figure 4E should have been different (the figures show two different cell lines). Figure 1 in this correction article is the correct version of Figure 4 from the original article [1]. The figure legend does not need to be changed.

thumbnailFigure 1. LPA3, but not or to lesser extent LPA1, LPA2, and LPA4, mediated the LPA-dpYAP effect. A, OVCA433 (a) and OVCAR5 (c) cells were starved and pretreated with Ki16425 (10 μM) for 1 hr prior to treatment with LPA (10 μM, 2 hr). pYAP was analyzed by Western blot. (b) The effect of Ki16425 on LPA (10 μM, 2 hr)-induced YAP nuclear translocation in OVCA433 cells. Green: YAP; red: DAPI. Representative results are shown. B, (a) The mRNA levels of LPA receptors after siRNA-treatment in OVCAR433 cells were determined by quantitative real-time PCR. Normalized expression values are given as percentage of control siRNA treated samples (means ± SD of three independent experiments). ***P < 0.001. (b) LPA (10 μM, 2 hr)-induced dpYAP effects were determined in LPA receptor specific siRNA-treated cells (48 hr post-transfection). (c) Quantitation of Western blots from (b) presented as fold decrease of pYAP after LPA stimulation compared to unstimulated controls. The data are means ± SD from three independent experiments. *P < 0.05. C, D and E, Cells were pretreated with PTX (100 ng/mL, 16 hr) or transfected with different dn plasmids for 48 hr, starved and then treated with LPA (10 μM, 2 hr). Cell lysates were analyzed by Western blot. Representative results are shown.


  1. Cai H, Xu Y: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells.

    Cell Communication and Signaling 2013, 11:31.

    doi:10.1186/1478-811X-11-31. PMID: 23618389

    PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL