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Open Access Correction

Correction: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Hui Cai12 and Yan Xu2*

Author Affiliations

1 First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China

2 Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 W. Walnut St. IB355A, Indianapolis, IN 46202, USA

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Cell Communication and Signaling 2013, 11:92  doi:10.1186/1478-811X-11-92


The electronic version of this article is the complete one and can be found online at: http://www.biosignaling.com/content/11/1/92


Received:4 December 2013
Accepted:4 December 2013
Published:13 December 2013

© 2013 Cai and Xu; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Correction

In the original paper published [1], there is a mistake in Figure 4. Figure 4D and Figure 4E are the same, but Figure 4E should have been different (the figures show two different cell lines). Figure 1 in this correction article is the correct version of Figure 4 from the original article [1]. The figure legend does not need to be changed.

thumbnailFigure 1. LPA3, but not or to lesser extent LPA1, LPA2, and LPA4, mediated the LPA-dpYAP effect. A, OVCA433 (a) and OVCAR5 (c) cells were starved and pretreated with Ki16425 (10 μM) for 1 hr prior to treatment with LPA (10 μM, 2 hr). pYAP was analyzed by Western blot. (b) The effect of Ki16425 on LPA (10 μM, 2 hr)-induced YAP nuclear translocation in OVCA433 cells. Green: YAP; red: DAPI. Representative results are shown. B, (a) The mRNA levels of LPA receptors after siRNA-treatment in OVCAR433 cells were determined by quantitative real-time PCR. Normalized expression values are given as percentage of control siRNA treated samples (means ± SD of three independent experiments). ***P < 0.001. (b) LPA (10 μM, 2 hr)-induced dpYAP effects were determined in LPA receptor specific siRNA-treated cells (48 hr post-transfection). (c) Quantitation of Western blots from (b) presented as fold decrease of pYAP after LPA stimulation compared to unstimulated controls. The data are means ± SD from three independent experiments. *P < 0.05. C, D and E, Cells were pretreated with PTX (100 ng/mL, 16 hr) or transfected with different dn plasmids for 48 hr, starved and then treated with LPA (10 μM, 2 hr). Cell lysates were analyzed by Western blot. Representative results are shown.

References

  1. Cai H, Xu Y: The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells.

    Cell Communication and Signaling 2013, 11:31.

    doi:10.1186/1478-811X-11-31. PMID: 23618389

    PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL