Table 3

JNK stimulating agents in prostatic cells

Agent
Cell line
Apoptosis
Ref

NDF/Heregulin
LNCaP
?
81
TGF-b
DU145, PC3
?
107,108
2-methoxyestradiol (2-ME)
LNCaP, PC3, Dunning Rat Model
Suggested
109
N-(4-hydroxyphenyl)retinamide (4-HPR)
LNCaP
+
49,50,57
Anisomycin (translation inhibitor)
DU145, PC3
+
62,71
Cryptophycin-52 (antimicrotubule agent)
LNCaP, DU145
+
110
Tumor necrosis factor (TNF)
LNCaP (mild), DU145
?
70
Grape seed extract
DU145
+
102
Selenite
DU145
?
104
Zinc
DU145, PC3
?
111
Methionine restriction
PC3
+
112
Phorbol esters
LNCaP
?
113
Thapsigargin
LNCaP
?
113
Arsenic trioxide
DU145, PC3
-
114
PEITC
LNCaP
+
68

Maroni et al. Cell Communication and Signaling 2004 2:5   doi:10.1186/1478-811X-2-5

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