|
Effect of rottlerin and of Ro 32-0432 on PMA-dependent inhibition of the [Ca++]i rise induced by TTN. Data are expressed as percentage of the effect of TTN alone, and are shown as the mean ± SD of at least 3 separate experiments. * = P < 0.05, ** = P < 0.01 vs TTN alone; # = P < 0.01 vs TTN + PMA. |
|
| TTN 100 μM |
100.0 ± 15.5 |
| TTN 100 μM + PMA 1 ng/ml |
29.3 ± 15.5** |
| TTN 100 μM + PMA 1 ng/ml |
|
| + rottlerin 3 μM |
25.0 ± 18.3** |
| + rottlerin 5 μM |
47.4 ± 15.1* |
| + rottlerin 10 μM |
61.5 ± 14.2* |
| TTN 100 μM + PMA 1 ng/ml |
|
| + Ro 32-0432 5 nM |
60.0 ± 13.2** |
| + Ro 32-0432 20 nM |
89.5 ± 14.7# |
| + Ro 32-0432 50 nM |
102.3 ± 15.1# |
Marino et al. Cell Communication and Signaling 2004 2:6 doi:10.1186/1478-811X-2-6 |
|