Figure 4.

The MAPK pathway in rVSMC is activated by different stimuli. The addition of FCS or PDGF-BB or the plating of rVSMC on fibronectin was sufficient to induce measurable increases in p44/p42 activation over 30 minutes. However, the addition of TGF-β1 or the plating of rVSMC on laminin-5 was not sufficient to induce MAPK activation.