Table 2

SH3 domain interaction partners of Nck

Protein
Reference

Abl
[107]

Ack1
[108]

ADAM15
[33]

Bcr-Abl
[109]

Casein kinase 1 (γ2)
[110]

Cbl
[26,111]

CD3ε
[34]

DCC
[112]

DOCK180
[113]

Dopamine D4 receptor
[114]

Dynamin
[101]

eIF2β
[105]

FAK
[115,116]

FasL
[90,91]

GC-NAP
[117]

hnRNPκ
[118]

HPK1
[119]

IRS-1
[120]

NAP1BP
[121]

NckAP1
[122]

NIK
[123]

N-WASP
[47]

PAK1
[73]

PAK3
[124]

PINCH
[125]

PRK2
[126]

RalGPS
[127]

R-Ras
[102]

Sam68
[95]

SOCS7
[93]

Sos
[99]

Synaptojanin
[118]

TBK1
[128]

TNIK
[129]

WASP
[30]

WIP
[31]

YAP65
[130]

Only in a few studies, interactions have been mapped to individual SH3 domains. In fact, several studies do not attribute a given interaction to an individual SH3 domain. Moreover, SH3 domains which do not contribute to a direct interaction might well influence binding in a cooperative manner. Thus, the reader is encouraged to consult the cited literature for further information on the Nck interacting protein of interest.

Lettau et al. Cell Communication and Signaling 2009 7:1   doi:10.1186/1478-811X-7-1