Review
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
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* Corresponding author: Raymond B Birge birgera@umdnj.edu
1 Department of Biochemistry & Molecular Biology, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
2 Department of Chemistry, Chemical Biology and Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA
3 Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, kita-ku, Sapporo, 001-0021, Japan
4 Department of Pathology, Division of Medicine, Hokkaido University School of Medicine, North 15, Kita-ku, Sapporo, 060-8638, Japan
Cell Communication and Signaling 2009, 7:13 doi:10.1186/1478-811X-7-13
Published: 10 May 2009Additional files
Additional file 1:
A rotational view of the Crk II structure is shown in the supplemental data. The organization of the SH2 and SH3 domains are indicated in order to illustrate negative regulation.
Format: GIF Size: 2.7MB Download file
Phenotype of Crki expressing cells. When Crk is downmodulated by siRNA, cells exhibit decreased motility and invasion.
Format: MOV Size: 3.9MB Download file
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Phenotype of Crki expressing cells. When Crk is downmodulated by siRNA, cells exhibit decreased motility and invasion.
Format: MOV Size: 4.2MB Download file
Playing the movie within this page requires QuickTime and JavaScript. Read more