 ReviewCrk and CrkL adaptor proteins: networks for physiological and pathological signalingRaymond B Birge1 1 Department of Biochemistry & Molecular Biology, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA 2 Department of Chemistry, Chemical Biology and Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA 3 Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, kita-ku, Sapporo, 001-0021, Japan 4 Department of Pathology, Division of Medicine, Hokkaido University School of Medicine, North 15, Kita-ku, Sapporo, 060-8638, Japan
Cell Communication and Signaling 2009, 7:13doi:10.1186/1478-811X-7-13
Additional filesAdditional file 1: A rotational view of the Crk II structure is shown in the supplemental data. The organization of the SH2 and SH3 domains are indicated in order to illustrate negative regulation. Format: GIF Size: 2.7MB Download file
Phenotype of Crki expressing cells. When Crk is downmodulated by siRNA, cells exhibit decreased motility and invasion. Format: MOV Size: 3.9MB Download file Playing the movie within this page requires QuickTime and JavaScript. Read more
Phenotype of Crki expressing cells. When Crk is downmodulated by siRNA, cells exhibit decreased motility and invasion. Format: MOV Size: 4.2MB Download file Playing the movie within this page requires QuickTime and JavaScript. Read more |
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