Table 1 |
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Examples of cellular and extracellular stimuli that result in Crk-mediated signal transduction: |
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Signals |
Tyrosine phosphorylation connection |
Biological outcome |
References |
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Cellular stimulation |
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v-Crk |
p130Cas, pp110, paxillin |
Cellular transformation |
Mayer et al (1988) Matsuda et al (1990) |
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v-Src |
p130Cas, paxillin, others |
Cellular transformation |
Sakai et al (1994) |
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Bcr-Abl |
p130Cas, PI3-kinase |
Cellular transformation, CML |
Sattler et al (1996) |
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Growth factor/Tyrosine kinase |
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NGF/TrkA |
TrkA, p130Cas |
Differentiation, neurite outgrowth |
Hempstead et al (1994) Ribon et al (1996) |
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EGF/Her proteins |
Cbl, p130Cas, BRK |
Proliferation, receptor internalization |
Fukazawa et al (1996) Ojaniemi et al (1997) |
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Insulin/IGF-1/IR/IGF-R |
p130Cas, IRS-1, 4BS |
Mitogenic Signaling |
Beitner-Johnson et al (1996), Jin et al (2000) |
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PDGF/PDGFRα |
PDGF-Rα, p130Cas |
Mitogenic Signaling |
Anderson et al (1990), Yokote et al (1998) |
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VEGF/VEGFR |
p130Cas |
Motility in endothelial cells, Angiogenesis |
Salameh et al (2005) |
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HGF/Met |
Gab1, PI3-kinase |
Epithelial morphogenesis |
Garcia-Guzman et al (1999) |
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Ephrin/EphB2 |
p130Cas, Cbl |
Membrane ruffling, tumor growth |
Noren et al (2006) |
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Cytokines/Receptors |
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IL-8/IL-8R |
p130Cas |
Cytoskeletal changes |
Schraw et al (1995) |
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IL-3/IL-3R; Epo-EpoR |
Cbl |
Proliferation |
Barber at al (1997) |
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Ang-2/Tie2 |
p130Cas |
Vascular smooth muscle cell migration |
Takahashi et al (1998) |
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Calcitonin-Calcitonin-R |
p105CasL |
Cytoskeletal changes |
Zhang et al (1999) |
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IL-2/IL2R |
STAT-5 |
Nuclear translocation/Transcription |
Oda et al (2000) |
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TGF-β/TGF-β1R |
p130Cas |
E-Cadherin cell to cell contact |
Kim et al (2002) |
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SLDF-1 |
p130Cas./JAK2 |
Cellular migration |
Zhang et al (2001) |
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Reelin/ApoER2 |
Dab1 |
Neuronal positioning |
Chen et al (2004) |
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Crosslinking TCR activation |
p130Cas, Cbl, ZAP70 |
Proliferation/Clonal expansion |
Sawasdiksol et al (1995), Buday et al (1996) |
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LFA/BCR activation |
p130Cas, Cbl |
B cell activation/differentiation |
Petruzzelli et al (1996) |
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LPA/Bombesin/RhoA |
p130Cas, paxillin |
Stress fiber formation/focal adhesions |
Flinn et al (1996) |
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GABA/m3 muscarinic-R |
FAK, p130Cas |
Exocytosis (pancreatic cells) |
Rasado et al (2000) |
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CCL20/CCR6 |
p130Cas |
Epithelial cell adhesion/migration |
Yang et al (2005) |
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Cell adhesion/Integrins/Mechanical force |
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FN/Integrin β1 |
p130Cas/FAK |
Cell adhesion and migration |
Nojima et al (1996) Armulik et al (2000) |
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uPA/uPAR |
p130Cas |
Motility in tumor cells |
Smith et al (2008) |
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MCSP/α4β1 integrin |
p130Cas |
Tumor invasion |
Eisenmann et al (1999) |
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Shear/Mechanical tension |
p130Cas |
Src activation/Focal adhesion remodeling |
Okuda et al (1999), Sawada et al (2006) |
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Col/Col-R |
Paxillin |
Cell Dispersion |
Petit et al (2000) |
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Osmotic Stress/Shock |
Gab1, p130Cas |
Stress responses |
Gaul et al (2002) |
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ECM proteins/Integrins |
p130Cas |
Rac1-mediated motility |
Cho et al (2000) |
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Laminin 10/11 |
p130Cas |
Cellular migration |
Gu et al (2001) |
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TIMP-2 |
Paxillin |
HVEC motility and invasion |
Oh et al (2006) |
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Chondroitin-Sul/Neuropilin |
p130Cas |
Axon guidance |
Liu et al (2007) |
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HLA |
ERM proteins |
Cell migration |
Tsuda et al (2004) |
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Particles |
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Apoptotic cells |
p130Cas |
Phagocytosis |
Reddien et al (2000), Albert et al (2000) |
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Molecular patterns/CD36 |
p130Cas |
Phagocytosis |
Stuart et al (2007) |
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Adenovirus/αvβ5 integrin |
p130Cas |
Virus endocytosis/trafficking |
Li et al (2000) |
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Yersinia |
p130Cas |
Pathogen uptake |
Weidow et al (2000) |
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Shigella |
p130Cas/Abl |
Bacterial uptake |
Burton et al (2003) |
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Listeria/InIB receptor |
Gab1 |
Bacterial Entry |
Sun et al (2005) |
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Helicobactor |
CagA |
Entry into Gastric cells |
Suzuki et al (2005) |
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Other |
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Fluoroaluminate |
p130Cas |
Spreading of pre-osteoblstic cells |
Freitas et al (2002) |
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Shingosine-1-phosphate |
p130Cas |
Gi-mediated motility |
Ohmori et al (2001), Endo et al (2002) |
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MFG-E8 |
p130Cas |
Phagocytosis |
Akakura et al (2004), Hamayama et al (2002) |
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Estrogen/Tamoxafin |
Gab1, p130Cas |
Non-genomic actions of E2 |
Cabodi et al (2004), Cowell et al (2006) |
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The data are arranged in potential classes of initiating signals, as well as major tyrosine phosphorylated scaffolds that assemble with Crk or CrkL. For specific examples, please see references [2,5,19-73] in the bibliography. |
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Birge et al. Cell Communication and Signaling 2009 7:13 doi:10.1186/1478-811X-7-13 |
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