Table 1 |
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Oncogenic events in human and murine leukemias involving Gab2 |
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Genetic aberration |
Leukemic disease |
Involvement of Gab2 |
References |
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|
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Bcr-Abl translocation t(9;22) |
CML, B-ALL |
Recruitment of Grb2/Gab2 complex to Y177 of Bcr-Abl Y177 and Gab2 are essential for Bcr Abl-mediated transformation and leukemogenesis |
|
|
Bcr-FGFR1 t(8;22) |
CML-like disease |
Recruitment of Grb2 and presumably Gab2 to Y177 of Bcr-Abl. Increased Gab2 tyrosine phosphorylation |
[186] |
|
Tel-Abl translocation t(9;12) |
B-ALL, T-ALL, CML |
Recrutiment of Grb2/Gab2 complex to Y314 of Tel-Abl Y314 is essential for Tel Abl-mediated transformation and leukemogenesis |
[191] |
|
Tel-Jak2 translocation t(9,12) |
ALL |
Some isoforms of Tel-JAK2 recruit the Grb2/Gab2 complex via Y314 |
[190] |
|
Npm-Alk translocation t(2;5) |
Anaplastic large cell lymphomas |
Gab2, SHP2 and Grb2 form a complex with Npm-Alk |
[242] |
|
SHP2 E76K point mutation |
JMML |
E76K mutation confers enhanced catalytic activity to SHP2 and requires Gab2 for transformation |
[200] |
|
Sf-Stk |
Friend's virus-induced erythroleukemia in mice |
Recruitment of the Grb2/Gab2 complex to Sf-Stk is essential for erythroid transformation by Friend virus, this involves the direct binding of STAT3 to Gab2 |
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|
Amplification of MLL locus |
AML/MDS |
Gab2 is frequently co-amplified with the mixed lineage leukaemia (MLL) gene |
[210] |
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Wöhrle et al. Cell Communication and Signaling 2009 7:22 doi:10.1186/1478-811X-7-22 |
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