Figure 1.

Domain structure of the Eps15 proteins. Different functional regions are indicated, green: Eps15 Homology or EH domains; light bleu: specific Eps15b region; dark blue: coiled-coil region; orange: binding site to α-adaptin; light green: binding site for γ-adaptin; purple: proline rich motifs (prm); red: ubiquitin interacting motifs (UIM) and blue: nuclear export signal (NES). Y850 tyrosine phosphorylation site in Eps15. Although Eps15b has multiple DPF motif it binds poorly to α-adaptin in vivo [29]. The sequences of the two UIMs are shown. Note the double serine and alanine motifs (in red) in the UIM2.