Email updates

Keep up to date with the latest news and content from CCS and BioMed Central.

Open Access Highly Accessed Open Badges Review

Mammalian Sirt1: insights on its biological functions

Shahedur Rahman and Rezuanul Islam*

Author Affiliations

Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia -7003, Bangladesh

For all author emails, please log on.

Cell Communication and Signaling 2011, 9:11  doi:10.1186/1478-811X-9-11

Published: 8 May 2011


Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.

Sirt1; mammalian sirtuin; cell aging