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Open Access Highly Accessed Review

Mammalian Sirt1: insights on its biological functions

Shahedur Rahman and Rezuanul Islam*

Author Affiliations

Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia -7003, Bangladesh

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Cell Communication and Signaling 2011, 9:11  doi:10.1186/1478-811X-9-11

Published: 8 May 2011

Abstract

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.

Keywords:
Sirt1; mammalian sirtuin; cell aging