RACK1 is an important regulator of Focal Adhesion assembly. When a cell is in contact with the Extracellular Matrix, integrins are clustered on the cell surface. This clustering of integrins leads to the recruitment of FAK and to the establishment of focal adhesions. At focal adhesions, RACK1 recruits key structural proteins, kinases and phosphatases to help nurture the developing focal adhesion. It is likely that at focal adhesions RACK1 brings in phosphodiesterases and ribosomes which facilitate local signaling and translation. A change in RACK1 expression (both up and down) has consequences for the activity and stability of RACK1-associated proteins and is believed to be a contributing factor in the development and progression of cancer.
Adams et al. Cell Communication and Signaling 2011 9:22 doi:10.1186/1478-811X-9-22