Figure 2.

Structural detail for RACK1 proteins. (A) Crystal structure of RACK1A from A. thaliana (PDB: 3DM0), illustrating the seven-bladed β-propeller structure. (B) As (A) but with surface rendition. (C) Schematic representation of RACK1 structure and organisation of WD-repeats (defined in Figure 6); peripheral circles show superimposition of individual propeller blades for Gβ1 (blue) (PDB: 1TBG) and for the structurally defined RACK1 orthologues from A. thaliana (green) (PDB: 3DM0), S. cerevisiae (orange) (PDB: 3FRX) and T. thermophila (pink) (PDB: 2XZN). Gβ is distinguished in blade 7 by a helical N-terminal extension that engages tightly bound Gγ (not shown) in coiled coil interactions.

Adams et al. Cell Communication and Signaling 2011 9:22   doi:10.1186/1478-811X-9-22
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