Model for cAMP/PKA-mediated nuclear translocation of RACK1. (A). In resting state, RACK1 forms homodimers as well as heterodimers with Gβ. (B). Activation of the cAMP/PKA pathway leads to the dissociation of RACK1 from the complex and its translocation to the nucleus. In the nucleus RACK1 contributes to cAMP/PKA mediated increase in BDNF transcription.
Adams et al. Cell Communication and Signaling 2011 9:22 doi:10.1186/1478-811X-9-22