Most Recent Articles: Cell Communication and Signalinghttps://biosignaling.biomedcentral.comMost Recent Articles: Cell Communication and SignalingFrom gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathyhttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01546-5Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatm...ReviewWed, 27 Mar 2024 00:00:00 GMThttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01546-5R. J. A. Veltrop, M. M. Kukk, K. Topouzidou, L. Didden, A. Muchir, F. G. van Steenbeek, L. J. Schurgers and M. Harakalova2024-03-27T00:00:00ZPolyploidy and mTOR signaling: a possible molecular linkhttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01526-9Polyploidy is typically described as the condition wherein a cell or organism has more than two complete sets of chromosomes. Occurrence of polyploidy is a naturally occurring phenomenon in the body’s developm...ReviewWed, 27 Mar 2024 00:00:00 GMThttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01526-9Debopriya Choudhury, Dhruba Ghosh, Meghna Mondal, Didhiti Singha, Ramesh Pothuraju and Pushkar Malakar2024-03-27T00:00:00ZRolapitant treats lung cancer by targeting deubiquitinase OTUD3https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01519-8Lung cancer is cancer with the highest morbidity and mortality in the world and poses a serious threat to human health. Therefore, discovering new treatments is urgently needed to improve lung cancer prognosis...ResearchWed, 27 Mar 2024 00:00:00 GMThttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01519-8Tongde Du, Quan Gu, Yonghui Zhang, Yujie Gan, Rongrui Liang, Wenzhu Yang, Ya Lu, Chenxin Xu, Jianzhong Wu, Rong Ma, Haixia Cao, Jingwei Jiang, Juan Wang and Jifeng Feng2024-03-27T00:00:00ZFrizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01585-yChemoresistance is associated with tumor relapse and unfavorable prognosis. Multiple mechanisms underlying chemoresistance have been elucidated, including stemness and DNA damage repair. Here, the involvement ...ResearchWed, 27 Mar 2024 00:00:00 GMThttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01585-yYuhong Xia, Shan Wang, Yu Sun, Wei Wang, Shijie Chang, Zhongbo Zhang and Chenghai Zhao2024-03-27T00:00:00ZM1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environmenthttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01560-7Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, t...ResearchWed, 27 Mar 2024 00:00:00 GMThttps://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01560-7Stefano Tacconi, Francesco Vari, Carolina Sbarigia, Diana Vardanyan, Serena Longo, Francesco Mura, Federica Angilè, Audrey Jalabert, Ferninand Blangero, Assia Eljaafari, Laurence Canaple, Daniele Vergara, Francesco Paolo Fanizzi, Marco Rossi, Claire Crola Da Silva, Elizabeth Errazuriz-Cerda…2024-03-27T00:00:00Z